When you upload to a drop zone, the system automatically creates a new study item for each document. The study items are created for the document type associated with the reference model ID and level determined by your folder and breadcrumb selections.

A “Blinded” drop zone is always displayed. If you upload to the Blinded drop zone and the document type allows unblinded documents, the Unblinded value of the document will be automatically set to No.

An “Unblinded” drop zone is also displayed if the following are true:

• The document type associated with the artifact has the Can be unblinded setting of “Yes”
• The study selected from the breadcrumb has the Study contains unblinded documents setting of “Yes”

If you upload to the Unblinded drop zone, the Unblinded value of the document will be automatically set to Yes.

To upload to a drop zone by browsing:

1. Click Browse Files in a drop zone.
2. Use the file explorer window to navigate to and select the documents you want to upload.
3. Click Open.

To upload to a drop zone by dragging and dropping:

1. Select one or more documents you want to upload from your local file explorer.
2. While holding the mouse button, drag the documents to the desired drop zone in eUpload. The text and image in the drop zone turn green.
3. Release the mouse button.

You can submit a document only if the document is eligible to be submitted. A document is eligible to be submitted if:

• An error was not encountered upon upload
• If the document has missing metadata, the system is configured to allow documents with incomplete metadata to be submitted
• The document is not multi-indexed

Note: If multi-indexed, you must work on the document from your eTMF Work Area.

To submit a single document, click the Submit button. If the document has missing metadata, a confirmation message displays, indicating that the document has incomplete metadata. Select Ok on the confirmation message.

To submit all documents, click the Submit All button. If any document has missing metadata, and the system is configured to allow you to submit documents with missing metadata, a confirmation message displays, indicating that one or more documents have incomplete metadata. Select Ok on the confirmation message.

For each document uploaded in eUpload, the following metadata fields are displayed. Fields that are required are displayed on the Review Files page in eUpload in yellow.

Field	Availability	Value	Editable
Doc Type ID	Always displayed	The doc type ID of the selected document	No
Ref Model Subtype	Only displayed if the document type is configured with Ref Model Subtype as an editable attribute	Blank if you uploaded to an artifact folder Otherwise, the name of the Ref Model Subtype folder you uploaded to	Yes
Subject	Only displayed if document type is configured with Subject as an editable attribute	For .msg files, the subject of the email is used as the subject of the document (with the exception of references to FWD and RE For other files, the file name is used as the subject of the document	Yes
Document Date	Always displayed	For Outlook .msg files, the sent date of the latest email is used as the document date For other files, the document date is blank	For non-.msg files only
Receipt Date	Always displayed	For Outlook .msg files, the receipt date of the latest email is used as the document date For other files, the receipt date is blank	For non-.msg files only
Language	Always displayed	The language is automatically detected when possible If auto-detection is not possible, then the language is blank	Yes
Program/Study	Always displayed	The program and study to which the document was uploaded	No
Country/Site	Displayed only if uploaded to a country or site	The country and site to which the country was uploaded (if applicable)	No
Organization	Always displayed	The organization for the document type; if multiple organizations are associated with the document type, only the first organization specified is displayed	No
Additional Information	Always displayed	Blank	Yes
Document Owner	Always displayed	The user who is logged into eUpload	Yes
Unblinded	Displayed only if study allows unblinded documents and the document type can be unblinded	Yes, if you uploaded to the Unblinded drop zone No, if you uploaded to the Blinded drop zone or if you uploaded to a study item and either the study does not allow unblinded documents or the document type cannot be unblinded Blank, if you uploaded to a study item, and the study can contain unblinded documents, and the document type can be unblinded	Yes
Restricted	Always displayed	Yes, if the document type is restricted No, if the document type is not restricted	No
Financial Interest Identified	Displayed only if the document type is configured to indicate that the document can contain financial interest information	Blank by default; select Yes or No to complete	Yes
IP Green Light	Displayed only if the document type is configured to indicate that the document can be relevant for a drug shipment	Blank by default; select Yes or No to complete	Yes

Note that your system may permit you to submit documents even if they do not have values in all required fields.

The Document Date, Receipt Date, and Language fields can be made “sticky” to retain the value you select and carry forward to other documents in the same review session. To use the “sticky” feature, select the push pin icon next to the field. In the image below, the push pin has been selected for the Receipt Date field.

You can return to the eUpload landing page (i.e., the folder view) from the Review Files page if you want to upload more files before submitting.

1. Click Close & Review Later.
2. On the confirmation dialog, select Confirm. Any metadata changes you’ve made to the currently selected document will not be saved.

You may want to delete a document from eUpload if the wrong content was uploaded, if the upload failed, or if the document was multi-indexed and must be processed from the eTMF (a warning is displayed in the right panel for the latter case).

To delete a document, click on the trash can icon in the left panel.

Note: If the document was multi-indexed, you must process the document in eTMF before deleting the document in eUpload.  If you delete the document from eUpload before you have processed the document in eTMF, the document will be deleted from eTMF as well.

If multiple documents are available on the left panel of the Review Files page, a Delete All button is displayed at the bottom of the page. You can use this button to delete all listed documents from both eUpload and from your eTMF Work Area (for example, if you uploaded the wrong files).

1. Click Delete All Files.
2. On the confirmation dialog, select Ok.

The Content Viewer in eUpload displays the PDF rendition of the first page of the document selected on left panel, allowing you to quickly verify that the correct content was uploaded. If you want to view all pages of content, you can select one of the following options from the Actions menu:

• View Native Content – downloads the file to your default download location in its original format, if not PDF (based on browser settings)
• View PDF in Browser – opens the document in a new browser tab or window
• View PDF in Acrobat – downloads the PDF rendition of the document to your default download location (based on browser settings)

If you are reviewing multiple documents, you can use the Sort feature to display the documents in the selected order. For example, you may want to review all documents with missing metadata first, so that you can complete indexing before submitting. In this situation, you can select “Metadata Status (Incomplete First)” from the sort menu. When sorting by metadata status, the system displays documents in the left panel in categorized lists, instead of in a single list. List categories include Missing Metadata, Metadata Complete, and Errors.

Documents listed under the Metadata Complete category have values in all required fields. Only Outlook .msg files can be listed under this category, as certain values are automatically extracted from the files upon upload (for example, Document Date, Language, etc.).

Note: Document Date and/or Receipt Date values may not be extracted from a .msg file if the file did not originate in Outlook (for example, an email in yahoo was sent to an Outlook account, downloaded from Outlook, and uploaded to eUpload).

Documents listed under the Missing Metadata do not have values in all required fields. You can choose to enter values before submitting. Or, if your environment is configured to allow submission of documents with incomplete metadata, you can submit these documents without having values in all required fields.

You can choose to review a single uploaded document by selecting the Review File link for the document in the right panel or to review multiple documents by selecting the Review All link in the right panel.

Selecting the link takes you to the Review Files page, where you can view a PDF rendition of the first page of the available documents, complete missing metadata (if needed), and submit.

On the left of the Review Files page, the document(s) available for review are displayed. If you selected to review only one document on the previous page, this list will contain only that document. If you selected to review all documents, the list will contain all documents available for review (i.e., documents that have not been deleted or submitted from eUpload). If the list displays multiple documents, you can use the sort options to display the documents in a logical order. For example, you may want to display all documents with incomplete metadata first.

A shaded indicator provides additional information about each document:

• Green (check mark) – all required metadata fields have values (Note: Only Outlook .msg files uploaded can have this indicator, as the system extracts specific metadata directly from the file during the upload)

• Yellow (!)- all required metadata fields do not have values
• Red (x) – document was not uploaded due to an error

When you select a document with a green or yellow indicator, the first page of the document’s content is displayed in the middle panel, and the document’s metadata fields are displayed in the panel to the right. You can complete empty fields or change fields values as appropriate. Any values you specify are not saved unless you submit the document.

When you select a document with a red indicator, the specific error encountered during upload is displayed in the panel to the right. Because the upload failed, your only choice is to delete the document.

You can choose to review and submit documents individually, or you can choose to submit all documents at once without reviewing. When a document is submitted, any changes to the metadata you’ve made in eUpload are saved, and the document is removed from eUpload. In addition, the document’s status may update to either InQC or Final, based on the completeness of the metadata and the system’s eUpload Workflow configuration.

Documents with complete metadata can always be submitted. Once submitted, these documents will either be sent to a QC task or automatically finalized, based on the configuration of your system.

Documents with missing metadata can be submitted only if your system is configured to allow the submission of documents with incomplete metadata. If your system is configured in this way, these documents will either be sent to an Indexing task or will remain in your eTMF Work Area for further indexing.

During the upload, a panel on the right displays the progress of each document. When an upload has finished, an indicator shows whether or not the upload completed successfully, with warnings, or failed.  

Note about uploading .msg files: When uploading a .msg file, the system checks to see if the email is part of an existing email thread in the study. If the system finds a match to an existing email thread, the uploaded document will be automatically indexed to that study item as a new version, even if that study item is associated with a different document type and/or level than the one uploaded to.

Note: An error will occur if the document is not a supported file type or if it is password protected.

Documents in the right panel are listed in categories that generally correspond to the way you uploaded. Documents uploaded to the Blinded drop zone are always displayed in the Blinded category, and documents uploaded to the Unblinded drop zone are always displayed in the Unblinded category. Documents uploaded to existing study items are displayed in the Study Items category, if the study allows unblinded documents and the document type can be unblinded. Otherwise, they are displayed in the Blinded category.

Documents that are uploaded without errors will immediately be available for review in eUpload and in the user’s eTMF Work Area.

Note about uploading .msg files: When uploading a .msg file, the system checks to see if the email is part of an existing email thread in the study. If the system finds a match to an existing email thread, the uploaded document will be automatically indexed to that study item as a new version, even if that study item is associated with a different document type and/or level than the one uploaded to.

If existing, ad hoc (and eUpload-eligible) study items are associated with the breadcrumb level and reference model folder you selected, they are displayed below the drop zones. You can upload a document directly to one of these study items as another version.

If the list of study items is lengthy, you can use the Search and Sort features in the header to locate a specific study item.

To upload to a study item:

1.  Select a document from your local file explorer.
2. While holding the mouse button, drag the document to the document icon until the icon is outlined in green and the text “+Copy” is displayed.
3. Release the mouse button. The system begins to upload the document.